Platelet Large Cell Ratio(PLCR)

Platelet-large cell ratio (P-LCR) reflects the proportion of platelets greater than 12 fL (Normal P-LCR is < 30% in the total platelet count). P-LCR is also considered as an indicator of risk factor associated with thromboembolic ischemic events [79]. P-LCR was inversely related to platelet count and directly related to PDW and MPV. Platelet large cell ratio if properly utilized can be a good aid in the differential diagnosis of conditions associated with abnormal platelet counts [80]. Larger platelets are usually relatively young, contain more intracellular granules and more thrombogenic potential. Platelet turnover play a significant role in platelets size. Inflammatory cytokines (interleukin 3 and interleukin 6) play a significant role in the regulation of platelet pool and leads to the production of larger platelets that are more reactive [81,82].