Immature Granulocytes (IG)

Determination of IG count is a component of FBC produced by a 5 -part differential haematology analyzer. Immature granulocytes are white blood cells that are not fully developed at the time of release from the bone marrow into the peripheral blood. Immature granulocytes include: promyelocytes, myelocytes and metamyelocytes. IG are precursors of neutrophils. With the exception of neonates or pregnant women and post-delivery the presence of IG in the peripheral blood indicates; early-stage response to infection, inflammation, tissue damage or presence of haematological malignancy. The presence of Ig in the peripheral blood is described as left shift. It is often a reflection of the bone marrow response to bacterial infection. Increased in IG is an early sign of bacterial infection and sepsis in adults. Early detection of bacteremia facilitates timely initiation of antimicrobial therapy, reduces morbidity and mortality and potentially decreases healthcare costs [83,84]. Immature granulocytes may predict severe acute pancreatitis independently of systemic inflammatory response syndrome.