Monday, December 4, 2023

Red Cell Distribution Width (RDW)

#Red Cell Distribution Width (RDW)

The red blood cell distribution width (RDW) is a measure of variation red blood cell (RBC) size. It is easily calculated by dividing the SD of erythrocyte volumes for the mean corpuscular volume. A modern refinement is the Red Cell Distribution width (RDW), which is a measurement of the variation in size of the RBC, and attempts to give a figure to the degree of anisocytosis, this being a morphological term indicating how much the cells vary in size.


 Causes of Normal RDW:

  • Thalassaemia
  • Acute blood loss anaemia
  • Anaemia of chronic disease
  • Spherocytosis
  • Aplastic anaemia
  • Preleukaemia


Causes of high RDW:

  • Iron deficiency anemia
  • Some haemolytic anaemias
  • Combined anaemias
  • Sickle cell anaemia
  • Sideroblastic anaemia
  • Chronic blood loss
  • B12/folate deficiency
  • Cold agglutinin

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